Of Flemish origins, to judge from the name by which he was known in Spain, his work reflects the innovation of the Bruges school in the last quarter of the 15th century, and in particular the work of Hugo van der Goes and Justus of Ghent.Having arrived in Spain, Juan de Flandes immediately settled in Burgos where he met Michel Sittow, a Flemish artist in the service of the Queen.Juan de Flandes’ first documented work (now fragmented) is the , a portable devotional work on which Michel Sittow also collaborated.
He was later based in Palencia, where there is a large reredos in the Cathedral.
In Palencia his wife was described as a widow in December 1519.
The overwhelming majority of his work held in collections outside Spain dates from this later period during which he concentrated on religious themes.
Panels from a large altarpiece from a Palencian church are divided between the Prado and National Gallery of Art, Washington, who have four panels each.
His works show the Early Netherlandish style of Ghent adapted to the Spanish taste and landscape, notably the requirements for groups of compartmented scenes for altarpieces.
His colouring is refined, "with a preference for rather acid hues", and "while his feeling for space and light is sophisticated, a tendency to divide space into a succession of thin planes becomes a mannerism in his late works".Juan de Flandes was painter to Queen Isabel the Catholic and is documented in Spain from 1496 onwards.Nothing is known of his life prior to his arrival in that country. 1460 – by 1519) was an Early Netherlandish painter who was active in Spain from 1496 to 1519; his actual name is unknown, although an inscription Juan Astrat on the back of one work suggests a name such as "Jan van der Straat".He was born around 1460 in Flanders (modern Belgium).He evidently trained in his home country, most likely in Ghent, as his work shows similarities to that of Joos van Wassenhove, Hugo van der Goes and other Ghent artists.